Unveiling the Oral-Systemic Axis: Exploring the Role of Microbiome and Osteoimmunology in Biological Dentistry

Biological Dentistry emerges as a burgeoning field acknowledging the intricate interplay between oral well being and systemic health.

This abstract delves into the indispensable role of the microbiome and osteoimmunology as pivotal elements influencing ove rall systemic health within the domain of dentistry. Within the oral cavity resides a myriad of diverse bacteria, viruses, and fungi, comprising a staggering 700 distinct species. These microorganisms, together with their byproducts and inflammatory mediat ors, have the potential to traverse various pathways, including ingestion via saliva, thereby potentially exerting an impact on other bodily regions.

Research studies have illuminated the significance of specific bacteria, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, not only in causing localized oral ailments but also in bearing systemic ramifications. Porphyromonas gingivalis has been associated with gut dysbiosis, as it manages to withstand the harshness of stomach acid an d disrupts the equilibrium of the gut microbiome. Additionally, the gingipain secreted by this bacterium has been implicated in the progression of Alzheimer’s disease. Conversely, Aggregatibacter actinomycetemcomitans has been discovered to heighten the me tastatic potential of pancreatic cancer. Rather than directly causing destruction, the inflammatory response triggered by these bacteria contributes to the deterioration of tooth supporting tissues and aggravates systemic inflammation.

Osteoimmunology, th e field that studies the interaction between the immune system and bone metabolism, offers valuable insights into the intricate relationship between inflammation and bone health. Previously viewed as relatively inert, bone is now recognized as a dynamic ti ssue undergoing constant remodeling. This process is governed by diverse factors, including RANKL (receptor activator of nuclear factor kappa B ligand) and OPG (osteoprotegerin), which regulate osteoclast activity. Bacterial lipopolysaccharides, such as th ose emanating from Porphyromonas gingivalis, have been demonstrated to enhance RANKL expression in osteoblasts, leading to bone loss in periodontal disease.

Appreciating these complex connections between oral health, the microbiome, osteoimmunology, and s ystemic health is of paramount significance within the realm of biological dentistry. By acknowledging the influence of oral pathogens and inflammation on systemic well being, a comprehensive approach can be embraced to foster both oral and overall health.

In the pursuit of enhancing osseointegration and implant stability, a pilot study was conducted utilizing a unique Ion Induction Therapy (IIT) protocol, along with IV Ozone. Preliminary results showcased remarkable outcomes, with Osstell ISQ scores avera ging 72 after 16 weeks post op. This data presents a notable advantage over a comparable study by Vladimir Kokovic et al., which achieved an average ISQ value of 64 for the same type of implant. Notably, ISQ scores above 70 indicate high stability, 60 69 s ignify medium stability, and scores below 60 denote low stability. This promising integration of IIT and IV Ozone highlights the potential to elevate osseointegration, thereby underlining the practical impact of these interventions in the realm of biologic al dentistry.

Further exploration through research endeavors and clinical investigations is warranted to advance our comprehension and devise effective strategies in biological dentistry, ultimately enhancing patient outcomes and systemic well being.

Dr. med. dent. Sebastjan Perko, Phd.
dr.perko@maha.si www.maha.si

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