Stopnja 6
STOPNJA DEDIFERENCIACIJE 6 JE ZADNJA STOPNJA, PRI KATERI JE GENSKI MATERIAL CELIC POŠKODOVAN IN PRIDE DO NOVE RASTI (RAKA).
ČE BOLNIKI ŠE VEDNO NE UKREPAJO S STRATEGIJO INTEGRATIVNE MEDICINE, KOPIČENJE ŠKODLJIVIH DEJAVNIKOV, IMENOVANIH TUDI »ODPADKI«, POŠKODUJE GENSKI MATERIAL CELICE IN MOČNO PRIZADENE MEHANIZME CELIČNEGA DIHANJA.
OKSIDATIVNI PROSTI RADIKALI POVZROČAJO ŠKODO NA ORGANIH IN POVEČUJEJO NJIHOVO DISFUNKCIJO IN DEGENERACIJO TKIVA. CELIČNO DIHANJE NI VEČ OKSIDATIVNO, AMPAK SE SPREMENI V FERMENTACIJO, TJ. WARBURGOV UČINEK.
Med diagnoze, ki spadajo v to skupino, spadajo načeloma vse oblike raka. Še zlasti na tej stopnji sodelujemo z našo partnersko kliniko iz Švice, Biomedicine Sonnenberg, ki ima veliko izkušenj na področju integrativne onkologije, in skupaj smo zelo uspešni.
INTEGRATIVNA ONKOLOGIJA IMA ŠIRŠE STRATEGIJE TERAPIJ in GREDO SKUPAJ S KLASIČNIMI TERAPIJAMI.
Na tej stopnji morajo biti terapije skrbno načrtovane, poleg vseh razlag iz prvih petih stopenj pa je na stopnji 6 obvezna tudi doslednost pri odstranjevanju kroničnih žarišč. Sem spadajo parodontalna bolezen, »mrtvi« zobje, kovine v ustni votlini in vse brazgotine po telesu. Ključnega pomena je delovanje črevesnega mikrobioma, saj 80 % imunskega sistema raste v stenah črevesja. Integrativna onkologija ponuja vrsto neposrednih protitumorskih snovi in posebnih krvnih testov za preizkušanje učinkovitosti kemoterapevtskih sredstev in sredstev integrativne medicine proti raku, da bi bile terapije čim bolj učinkovite. Vse druge strategije so v bistvu enake kot pri prejšnjih stopnjah, saj mora telo še vedno razbremeniti nakopičenih odpadnih snovi.
Ta stopnja je končna posledica neuspešnega nadzora kopičenja eksogenih in endogenih škodljivih dejavnikov. Prosti radikali še naprej povzročajo motnje v delovanju organov in degeneracijo tkiva. Celična presnova ni več oksidativna fosforilacija, ampak se spremeni v »fermentacijo«, kar pomeni »dihanje« na celični ravni. Dediferencirane celice se nato sprostijo v krvni obtok. Na splošno se moramo na tej stopnji zavedati, da so se močno zmanjšale energijske zaloge organizma ter njegova sposobnost uravnavanja.
Stopnja 5
STOPNJA DEGENERACIJE JE ZAZNAMOVANA Z GLOBLJIMI ZNOTRAJCELIČNIMI ŠKODLJIVIMI DEJAVNIKI, KI JIH SPREMLJA ZMANJŠANO DELOVANJE CELIC.
CELICE SO ŽE MOČNO POŠKODOVANE. KLJUČNEGA POMENA JE OBNOVA CELIČNE MEMBRANE, ENCIMOV, PREOSTALIH BELJAKOVIN IN GENSKEGA MATERIALA.
SPUŠČAMO SE ČEDALJE GLOBLJE. ANATOMIJA ORGANOV IN NJIHOVA FUNKCIJA JE VSE BOLJ IN NEPOPRAVLJIVO POŠKODOVANA. OBNOVITEV CELIČNE MEMBRANE, ENCIMOV, PREOSTALIH BELJAKOVIN IN GENSKEGA MATERIALA JE KLJUČNEGA POMENA ZA PREPREČITEV PREHODA V NASLEDNJO NAJBOLJ NEŽELJENO STOPNJO 6.
Če terapevtsko načrtovano razstrupljanje z drenažo v kombinaciji z restitucijskimi terapijami ni izvedeno in se uporabljajo le zaviralna zdravila, se zgradba organov in njihovo delovanje vedno bolj in nepopravljivo poškodujeta.
Tipične diagnoze v stopnji 5 so dermatozne bolezni, vključno z luskavico, parodontalna bolezen, atrofični rinitis, Parkinsonova bolezen, Alzheimerjeva bolezen, ALS, degeneracija makule, glavkom, Addisonova bolezen, KOPB, Chronova bolezen, ulcerozni kolitis, Hashimotova bolezen, sklerodermija, osteoporoza, artroza, ankilozirajoči spondilitis, miokardni infarkt itd.
POSTOPKI ZA ZAŠČITO IN POPRAVLJANJE GENETSKEGA IN NEGENETSKEGA MATERIALA CELICE
Terapije se nadaljujejo v smeri aktivacije splošnih telesnih obrambnih mehanizmov, da se z nevroterapijo, homeopatijo, zelišči, ozonoterapijo, akupunkturo itd. doseže učinkovita reaktivna stopnja 1 in 2. Pri ciljni antioksidativni terapiji, o kateri smo pisali drugod, se na tej stopnji še naprej proizvajajo reaktivne kisikove vrste. Aktivacija drenaže organov in zunajceličnega matriksa v mikroskopskem svetu pomeni drenažo celic s posebnim ortomolekularnim razstrupljanjem, zeliščno savno, drugimi medicinskimi ajurvedskimi tehnikami, hidroterapijo debelega črevesa ali klistirji itd. Potrebno je povečati membranski potencial, ker se ta ob poglabljanju bolezenskega stanja znižuje, z alkalnimi minerali, kot so magnezij, kalij, kalcij, in tudi z esencialnimi maščobnimi kislinami. Med številnimi terapevtskimi pristopi je v tem primeru izredno učinkovit Papimi. Tudi v tem primeru je treba posebno pozornost nameniti uporabi zaviralnih farmacevtskih sredstev ter pametnemu in skrbnemu prilagajanju odmerjanja. Med obravnavo je treba predpisati in načrtovati ortomolekularno strategijo. Kot vedno je najpomembnejši del, nad katerim imate kot bolnik popoln nadzor, poskrbeti za ustrezno hidracijo in zmanjšati antigensko in toksično obremenitev s prehrano.
V celicah prihaja do nenehnih degenerativnih poškodb, ki vplivajo na genetske in druge zgradbe, kot so membrane, encimi, preostale beljakovine itd. Neizogibno kopičenje toksinov se nadaljuje, kar se s kroničnim vnetjem samo še povečuje. Na tej stopnji lahko rečemo, da toksini zaradi impregnacije žlez povzročajo hormonsko neravnovesje in zmanjšano sposobnost imunomodulacije. Na koncu se obrambni mehanizem telesa v smislu vnetja in celic tako zavre, da pride do razmnoževanja anomalnih celic. Na tej stopnji so možne izboljšave, vendar lahko rečemo, da popolna ozdravitev morda ne bo mogoča niti z integrativnim pristopom. Vendar je s sodobnim povezovanjem vseh medicinskih znanj in dolgotrajnim zdravljenjem vse mogoče. Poudarek je vedno na podpori delovanja celic in izboljšanju prizadetih funkcij. Tudi tu ne smemo pozabiti na ustrezno ustno higieno, o kateri je govora drugje. Celična podpora se načrtuje na podlagi diagnostike, glavni cilj pa je povečati proizvodnjo energije ATP z vitamini, zelišči, homeopatskimi in podpornimi terapijami, kot so lokalna radiofrekvenčna hipertermija z ionsko indukcijsko terapijo Papimi in številne druge. Na ta način celice dobijo osnove za povrnitev svoje specifične funkcije in sposobnosti izločanja stranskih produktov presnove in strupenih snovi.
Stopnja 4
STOPNJA 4: ŠKODLJIVI DEJAVNIKI SO PRODRLI V CELICE. STRATEGIJA TERAPIJ MORA VKLJUČEVATI CELIČNO RAZSTRUPLJANJE.
NA TEJ STOPNJI ŠKODLJIVI DEJAVNIKI POŠKODUJEJO CELIČNE MEMBRANE, ENCIME ITD.
STOPNJA 4 POMENI PREHOD BOLEZNI IZ ZUNAJCELIČNEGA MATRIKSA V SPECIALIZIRANE CELICE ORGANOV S SOČASNIMI RESNEJŠIMI DIAGNOZAMI POŠKODB ORGANOV.
Med diagnoze, ki spadajo v to stopnjo, uvrščamo migreno, trzanje oči, virusne okužbe, astmo, razjede, toksične poškodbe jeter, nefrotski sindrom, avtoimunski glomerulonefritis, kronični artritis, benigno hiperplazijo prostate, bronhitis, angino pektoris, miokarditis in številne druge.
Strategija terapij v tej stopnji je bolj zapletena, takoj pa je dobro podpirati celične procese. Nujno je treba začeti s spodbujanjem celičnih energijskih mehanizmov z ortomolekularno terapijo, ionsko indukcijsko terapijo, hipertermijo, spodbujanjem katalizatorjev cikla citronske kisline, koencimom Q10, alfa lipoično kislino, vitaminom C, posebnimi zelišči in številnimi drugimi. Na ta način dajemo celicam energijo, ki jo potrebujejo za izločanje motečih dejavnikov v zunajcelični matriks in ohranjanje delovanja organov. Ker je zunajcelični matriks postal »odlagališče«, moramo hkrati aktivirati drenažo zunajceličnega matriksa in vseh organov izločanja, torej jeter, ledvic, kože, črevesne sluznice, in sicer z ortomolekularnimi zdravili, zelišči, posebnimi rastlinskimi toniki in olji ter določenimi terapijami. Ne smemo pozabiti na nevtralizacijo reaktivnih kisikovih vrst. Na nek način gre za sprožitev učinkovite druge stopnje, ki lahko iz telesa odstrani moteče škodljive dejavnike. Omenjeno podpiramo z nevralno terapijo, ozonom, vakuumsko terapijo, številnimi ajurvedskimi tehnikami in drugim. Povečanje membranskega potenciala dosežemo z ionsko indukcijsko terapijo Papimi in Indiba, ki jo spremljajo minerali, esencialne maščobne kisline itd. Farmacevtski izdelki se uporabljajo z zavedanjem, da zatiranje na tej stopnji ni zaželeno. Po drugi strani pa moramo biti na tej stopnji izjemno strogi glede zdravja ust, saj lahko veliko vzrokov izvira iz ust, kot so infekcijsko vnetje kosti in mehkih tkiv (parodontitis, »granulom« – mrtvi zobje), neinfekcijski FDOJ z izločanjem CCl5, materiali (kovine in plastika), pa tudi učinki ugriza na posturalne težave. Nazadnje je seveda treba bolj strogo upoštevati prehrano, hidracijo itd.
Tako opažamo neposredne učinke na celične funkcije, npr. encime, pa tudi na celične membrane in mitohondrije. Kot je zapisal Reckeweg, se na tej stopnji običajno srečamo z bolnikom, ki ima neko obliko kroničnega vnetja. V osnovi gre za vnetje v zunajceličnem matriksu, ki zaradi svoje kroničnosti pušča škodljive posledice. Celotno biokemično neravnovesje se kopiči okoli parenhima organa, vnetje pa je le reakcija druge stopnje, ki poskuša izolirati škodljive razmere z »brazgotinjenjem«. Na koncu ta proces poškoduje organ. Če ne zdravimo trenutne obrambe in ne začnemo z razstrupljanjem, je degeneracija organov neizogibna.
Stopnja 3
STOPNJA 3: TELO S SVOJIMI OBRAMBNIMI PROCESI NE ZMORE V CELOTI IZLOČITI TOKSINOV.
NALAGAJO SE V ZUNAJCELIČNEM MATRIKSU, V MAŠČOBNEM TKIVU IN V CELOTNEM ŽILNEM
SISTEMU.
NA TEJ STOPNJI JE NUJNO POTREBNO SPODBUDITI CELIČNI METABOLIZEM, DA SE ZNEBIMO NALOŽENIH SNOVI KAKRŠNEGA KOLI IZVORA.
ZARADI ODLAGANJA ŠKODLJIVIH SNOVI V VEZIVNEM TKIVU SE MORAJO AKTIVIRATI OBRAMBNI MEHANIZMI IZ STOPENJ 1 IN 2. POTREBNO JE AKTIVIRATI DRENAŽO IN TERAPIJE, KI SO SPECIFIČNE ZA IMUNSKI SISTEM.
Diagnoze na tej stopnji so ateromi, bradavice, ciste, polipi, nevromi, zaprtje, žolčni kamni, debelost, protin, edemi, otekanje limfnih žlez, hipertrofija prostate, fibroidi in revmatizem, če omenimo le nekatere.
POSEBNA DRENAŽA VEZIVNEGA TKIVA IN AKTIVACIJA RAZSTRUPLJANJA NA CELIČNI RAVNI
- Posebna zelišča in dopolnila za drenažo,
- usmerjeni ajurvedski tretmaji,
- osteopatske drenažne terapije,
- program ionske indukcijske terapije Papimi,
- specifična lokalna in sistemska hipertermija,
- IHHT: intermitentna hiper-, hipoksična terapija,
- integrativno zobozdravstvo.
Na splošno je mogoče prve tri stopnje obravnavati zelo uspešno, če so terapije ustrezno načrtovane in integrirane. Ne smemo pozabiti, da te tri stopnje vplivajo na telesno tekočino (vodo) in zunajcelični matriks, biokemični mehanizmi celice pa še niso poškodovani. Zavedati se moramo, da od tretje stopnje do naslednje četrte stopnje organizem nima učinkovite biološke obrambe in jemlje energijo iz procesov razstrupljanja. Celične presnovne funkcije potrebujejo spodbudo z načrtovanimi terapijami, da si opomorejo in podprejo sproščanje in postopno izločanje naloženih toksinov ter tako ohranijo energijo za vitalne organe.
Terapevtske strategije na tej stopnji so podobne tistim na prejšnji stopnji. To pomeni, da aktiviramo telesu lastno drenažo skozi ledvice, jetra, kožo in črevesno sluznico ter drenažo zunajceličnega matriksa skozi limfni in žilni sistem. To lahko dosežemo s kombinacijo ajurvedske zeliščne medicine, ortomolekularne terapije z dodatki ali infuzijami ali obojim, medicinskimi savnami, klistirji ali črevesno hidroterapijo, vakuumsko terapijo, homeopatijo in drugimi. Kadar se obrambni mehanizem stopnje 2, t.j. vnetja, podaljša, moramo biti pozorni na oksidacijske procese. Na podlagi laboratorijskih rezultatov in naših izkušenj predpišemo visoke odmerke antioksidantov. Tudi v tem primeru je pregled načina prehranjevanja bistvenega pomena, da se zagotovi ustrezna hidracija in zmanjša antigenska obremenitev hrane. Bistvena je aktivacija organov, ki proizvajajo imunske celice, kot sta kostni mozeg in timus. Ne smemo pozabiti na sekundarne limfoidne organe. Ti organi vključujejo bezgavke, vranico, tonzile in nekatera tkiva v različnih slojih sluznice telesa (npr. Peyerjeve zaplate v črevesju).
Stopnja 2
STOPNJA 2: STOPNJA REAKCIJE, ZA KATERO JE ZNAČILNO, DA IZLOČA ŠKODLJIVE DEJAVNIKE, KI SO LAHKO NOTRANJEGA ALI ZUNANJEGA IZVORA.
NA TEJ STOPNJI SE AKTIVIRAJO NARAVNI OBRAMBNI MEHANIZMI TELESA. NAJPOGOSTEJŠI SO BRUHANJE, DRISKA, VROČINA IN VNETJE.
STOPNJA 2: AKTIVIRANJE OBRAMBNIH MEHANIZMOV. PODPORA OBRAMBNIH SPOSOBNOSTI ORGANIZMA IN CILJNO DIAGNOSTICIRANEGA »ŠKODLJIVEGA DEJAVNIKA« S POSEBNIMI NEINVAZIVNIMI ALI INVAZIVNIMI TERAPIJAMI.
Sem spadajo dermatitis, eritem, ekcem, stomatitis, rinitis, herpes zoster, poliomielitis, nevralgijo, faringitis, laringitis, kolitis, hepatitis, absces, osteomielitis, tonzilitis in poliartritis.
DOLOČANJE SPECIFIČNEGA VZROČNEGA »ŠKODLJIVEGA” DEJAVNIKA, KI JE BIL ODKRIT MED ANAMNEZO IN DIAGNOSTIKO.
- Kemične snovi (glifosat, PFOA, pesticidi, DDT, herbicidi)
- Bakterije (streptokoki, stafilokoki, borelije itd.) – najpomembnejše
- Virusi (EBV, VZV, CMV, gripa, COVID-19 itd.) – najpomembnejši
- Težke kovine (arzen, kadmij, svinec, živo srebro itd.)
Najpogostejši obrambni mehanizmi so vročina, driska in vnetje, ki so neprijetni so pa zelo učinkoviti. V integrativni medicini se simptomi obravnavajo kot resen poskus telesa, da bi se vrnilo nazaj v prvo stopnjo v zdravje. Simptomi, čeprav so moteči, postanejo dragoceni znaki, da se organizem poskuša uravnavati v smeri okrevanja. Le v redkih primerih so potrebna zdravila proti vročini, bolečini in vnetju. Poleg tega lahko prekomerna uporaba tako imenovanih nesteroidnih protivnetnih zdravil povzroči napredovanje bolezni v globlje stopnje. V nekaterih primerih se uporabljajo, odmerek pa je potrebno skrbno izbrati.
Terapevtske strategije na tej stopnji so aktiviranje drenaže organov, kot so ledvice, jetra, koža in črevesna sluznica, ter drenaže zunajceličnega matriksa, kot je opisano drugje. To lahko dosežemo s kombiniranjem ajurvedske zeliščne medicine, ortomolekularnih terapij s prehranskimi dopolnili, infuzijami ali obojim, zdravilnimi savnami, klistirji ali hidroterapijo debelega črevesa, homeopatijo in drugimi. Kadar je vnetje dolgotrajno, moramo biti pozorni na reaktivne oksidativne vrste. Na podlagi laboratorijskih rezultatov in naših izkušenj moramo biti pozorni na visoko vsebnost antioksidantov. Ponovno je treba pregledati način prehranjevanja, da zagotovimo ustrezno hidracijo in zmanjšamo antigensko obremenitev hrane.
Stopnja 1
STOPNJA 1: SKRB ZA REDNO DNEVNO IZLOČANJE IN OHRANJANJE ZDRAVJA.
NA TEJ STOPNJI BI MORALE NARAVNE TELESNE POTI RAZSTRUPLJANJA DELOVATI NEMOTENO.
SKRB ZA REDNO DNEVNO IZLOČANJE IN OHRANJANJE ZDRAVEGA STANJA.
Primerno izločanje je predpogoj za normalno delovanje človeškega telesa v vsakdanjem življenju. Ta stopnja se vedno obravnava s terapijami, ne glede na diagnozo. Zagotoviti moramo normalno delovanje številnih endogenih mehanizmov razstrupljanja in ukrepati ob prvih znakih notranjih ali zunanjih škodljivih dejavnikov, ki ovirajo izločanje. Poti izločanja so znoj, sebum, slina, izločki prebavil, žolč, sok trebušne slinavke, menstruacija, limfa, urin, blato, menstruacija, seme itd. V primeru nagnjenosti h zaprtju je že potrebno ukrepati.
Izločanje škodljivih snovi običajno poteka prek fizioloških telesnih odprtin. Tako se lahko prehodno pojavi bruhanje ali driska in običajno je potreba nadomestiti le tekočino in elektrolite.
Običajno laboratorijsko preizkušamo glavne poti izločanja v krvi, na primer glutation transferazo, superoksid dismutazo, cistatin C in druge. Presenetljivo je, da je treba vse te encime za razstrupljanje aktivirati.
VAŠA KLJUČNA VLOGA:
Tekočine sestavljajo večino našega telesa, zato je pomembno, da poskrbimo za hidracijo. Voda je medij, v katerem potekajo vse biokemične reakcije, in če je ni dovolj, biokemija v telesu ne more delovati. Podobno je, kot če bi želeli žlico soli raztopiti v kozarcu vode.
Svetujemo, da je hrana ekološka in, če je le mogoče, lokalno pridelana. Izogibajte se vsem predelanim živilom, tudi če so ekološka. Pogosto opravimo preiskave na glifosat v krvi in niti ni presenetljivo, da je pogosto povišan. Eden izmed bolnikov je bil celo pozitiven na DDT, ki je v EU že dolgo prepovedan. Vedno svetujemo izogibanje izdelkom iz kravjega mleka zaradi povišane ravni beta-laktoglobulina in vsi naši bolniki so zelo zadovoljni, ko to storijo. Običajno svetujemo uživanje čim manj glutena in seveda strogo izogibanje sladkorju. Prehrana, ki jo svetujemo ima osnovo v “jakosti” presnove in ločimo prehrano za počasen, srednji ali hiter metabolizem. Tukaj se ugotavlja stanje prepustnosti črevesja in nato IgG4 protitelesa v krvi. Med terapijami, ki jih predpišemo, se postreže tudi primerna prehrana. Zanimivo je tudi, da se v t.i. Detox Profilu izkaže, da imamo pogosto premalo reduciranega glutationa in nizko aktivnost superoksidne dismutaze.
Biological dentistry: fundamentals and effective Methods: Preventive measures and therapeutic approaches to promote bone and soft tissue healing.
Biological dentistry: fundamentals and effective Methods: Preventive measures and therapeutic approaches to promote bone and soft tissue healing.
Biological Dentistry is a dynamic field that recognizes the intricate interplay between oral health and systemic well-being. This abstract provides a comprehensive exploration of the core principles and practical applications within Biological Dentistry, highlighting its significance in the context of modern healthcare’s shift towards prioritizing healthspan over mere lifespan.
At the heart of Biological Dentistry lies the profound recognition that oral health is not an isolated concern but an integral component of overall well-being. This understanding begins with a detailed examination of the microbiome and osteoimmunology, two pillars that underpin the biological mechanisms governing oral health.
The oral cavity houses a thriving ecosystem, hosting a diverse community of microorganisms, including over 700 distinct bacterial species, viruses, and fungi. These inhabitants, along with their metabolites and pro-inflammatory mediators, wield a remarkable capacity to exert influence far beyond their immediate domain. Specific attention is devoted to pathogenic microorganisms such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. These bacteria, recognized for their roles not only in causing localized oral conditions but also in driving systemic implications, illustrate the interconnectedness of oral and systemic health. Porphyromonas gingivalis, for instance, has been closely associated with gut dysbiosis and its potential to disrupt the gut microbiome equilibrium. Additionally, the secretion of gingipain by this bacterium has been implicated in the progression of Alzheimer’s disease. Likewise, Aggregatibacter actinomycetemcomitans is examined for its potential to heighten the metastatic potential of pancreatic cancer, thereby highlighting the systemic consequences of oral health. Crucially, the influence of these bacteria often manifests through inflammatory responses, reinforcing the central role of inflammation in both local and systemic pathologies.
Osteoimmunology, a burgeoning field investigating the intricate interaction between the immune system and bone metabolism, assumes critical importance in comprehending the complex relationship between inflammation and bone health. A paradigm shift from viewing bones as static structures to dynamic, continuously remodeling tissues is articulated. The regulatory mechanisms governing this remodeling process, notably RANKL (receptor activator of nuclear factor kappa B ligand) and OPG (osteoprotegerin), which modulate the activity of osteoclasts, are elucidated. Particular emphasis is placed on the influence of bacterial lipopolysaccharides, with Porphyromonas gingivalis as a notable example. These lipopolysaccharides have been shown to upregulate RANKL expression in osteoblasts, ultimately leading to bone loss in periodontal disease.
This exploration underscores the critical need to recognize the intricate connections between oral health, the microbiome, osteoimmunology, and systemic well-being. Such recognition not only underscores the need for a comprehensive approach but also aligns with the evolving paradigm of modern healthcare, which increasingly focuses on healthspan over lifespan. Today’s healthcare system recognizes that longevity alone does not equate to quality of life. Instead, the emphasis is shifting towards enhancing healthspan – the period of life marked by good health and well-being. In this context, Biological Dentistry takes on a pivotal role, as it acknowledges that oral health is an integral element of overall healthspan.
In conclusion, this comprehensive exploration underscores the vital importance of Biological Dentistry within the evolving landscape of modern healthcare. It serves as a compelling argument for healthcare systems to prioritize healthspan, promoting both oral and overall health through a deeper understanding of the connections between oral health, the microbiome, osteoimmunology, and systemic well-being. This paradigm shift represents a crucial step towards enhancing the quality of life for individuals across the lifespan.
Unveiling the Oral Systemic Axis: Exploring the Role of Microbiome and Osteoimmunology in Biological Dentistry
Unveiling the Oral-Systemic Axis: Exploring the Role of Microbiome and Osteoimmunology in Biological Dentistry
Biological Dentistry emerges as a burgeoning field acknowledging the intricate interplay between oral well being and systemic health.
This abstract delves into the indispensable role of the microbiome and osteoimmunology as pivotal elements influencing ove rall systemic health within the domain of dentistry. Within the oral cavity resides a myriad of diverse bacteria, viruses, and fungi, comprising a staggering 700 distinct species. These microorganisms, together with their byproducts and inflammatory mediat ors, have the potential to traverse various pathways, including ingestion via saliva, thereby potentially exerting an impact on other bodily regions.
Research studies have illuminated the significance of specific bacteria, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, not only in causing localized oral ailments but also in bearing systemic ramifications. Porphyromonas gingivalis has been associated with gut dysbiosis, as it manages to withstand the harshness of stomach acid an d disrupts the equilibrium of the gut microbiome. Additionally, the gingipain secreted by this bacterium has been implicated in the progression of Alzheimer’s disease. Conversely, Aggregatibacter actinomycetemcomitans has been discovered to heighten the me tastatic potential of pancreatic cancer. Rather than directly causing destruction, the inflammatory response triggered by these bacteria contributes to the deterioration of tooth supporting tissues and aggravates systemic inflammation.
Osteoimmunology, th e field that studies the interaction between the immune system and bone metabolism, offers valuable insights into the intricate relationship between inflammation and bone health. Previously viewed as relatively inert, bone is now recognized as a dynamic ti ssue undergoing constant remodeling. This process is governed by diverse factors, including RANKL (receptor activator of nuclear factor kappa B ligand) and OPG (osteoprotegerin), which regulate osteoclast activity. Bacterial lipopolysaccharides, such as th ose emanating from Porphyromonas gingivalis, have been demonstrated to enhance RANKL expression in osteoblasts, leading to bone loss in periodontal disease.
Appreciating these complex connections between oral health, the microbiome, osteoimmunology, and s ystemic health is of paramount significance within the realm of biological dentistry. By acknowledging the influence of oral pathogens and inflammation on systemic well being, a comprehensive approach can be embraced to foster both oral and overall health.
In the pursuit of enhancing osseointegration and implant stability, a pilot study was conducted utilizing a unique Ion Induction Therapy (IIT) protocol, along with IV Ozone. Preliminary results showcased remarkable outcomes, with Osstell ISQ scores avera ging 72 after 16 weeks post op. This data presents a notable advantage over a comparable study by Vladimir Kokovic et al., which achieved an average ISQ value of 64 for the same type of implant. Notably, ISQ scores above 70 indicate high stability, 60 69 s ignify medium stability, and scores below 60 denote low stability. This promising integration of IIT and IV Ozone highlights the potential to elevate osseointegration, thereby underlining the practical impact of these interventions in the realm of biologic al dentistry.
Further exploration through research endeavors and clinical investigations is warranted to advance our comprehension and devise effective strategies in biological dentistry, ultimately enhancing patient outcomes and systemic well being.
Author:
Dr. med. dent. Sebastjan Perko, Phd.
dr.perko@maha.si www.maha.si
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Biological Dentistry is an emerging field that recognizes the interplay between oral health and systemic health.
Biological Dentistry is an emerging field that recognizes the interplay between oral health and systemic health.
Biological Dentistry is an emerging field that recognizes the interplay between oral health and systemic health. This abstract explores the pivotal role of the microbiome and osteoimmunology as key factors influencing overall systemic health in the context of dentistry.
The oral cavity harbors a diverse array of bacteria, viruses, and fungi, with over 700 different species residing in the mouth. These microorganisms, along with their byproducts and inflammatory mediators, can travel through pathways such as saliva ingestion, potentially impacting other parts of the body.
Studies have revealed that certain bacteria, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, not only cause localized oral diseases but can also have systemic implications. Porphyromonas gingivalis has been linked to gut dysbiosis, surviving stomach acid and disrupting the gut microbiome. Moreover, gingipain secreted by this bacterium has been implicated in the development of Alzheimer’s disease. Aggregatibacter actinomycetemcomitans, on the other hand, has been found to increase the metastatic potential of pancreatic cancer. The inflammatory response triggered by these bacteria, rather than their direct destruction, contributes to the breakdown of tooth-bearing tissues and feeds into systemic inflammation.
Osteoimmunology, the study of the interaction between the immune system and bone metabolism, provides insights into the complex relationship between inflammation and bone health. Bone, once considered relatively inert, is now recognized as a dynamic tissue undergoing constant remodeling. This process is regulated by various factors, including RANKL (receptor activator of nuclear factor kappa B ligand) and OPG (osteoprotegerin), which modulate osteoclast activity. Bacterial lipopolysaccharides, such as those from Porphyromonas gingivalis, have been shown to increase RANKL expression in osteoblasts, resulting in bone loss in periodontal disease.
Understanding these intricate connections between oral health, the microbiome, osteoimmunology, and systemic health is of utmost importance in biological dentistry. By considering the impact of oral pathogens and inflammation on systemic health, a comprehensive approach can be adopted to promote oral and overall well-being. Further research and clinical investigations are warranted to advance our understanding and develop effective strategies in biological dentistry to improve patient outcomes and systemic health.
Blood Tests to Determine the Impact of the Mouth on the Body
Blood Tests to Determine the Impact of the Mouth on the Body
Integrative medicine does not exist without biological dentistry. The mouth with teeth is part of the body that, with its inflammatory conditions and metallic materials, affects health.
At the same time, any body therapy cannot be effective if the body is burdened with oral conditions. Infections can lead to periodontitis or periodontal disease, “dead” teeth with granulomas, and among the metals, there is amalgam containing mercury, as well as most metallic alloys used in bridges and dentures. Inflammation creates an acidic environment, accelerating the “dissolution” of metals that deposit in the body.
In biological dentistry, thorough diagnostics are crucial, including oral examinations, even with a microscope, computer analysis of the periodontal disease status, X-rays, including CBCT, Dark Field microscopy, analysis of inflammatory mediators, etc.
When the diagnostics reveal what needs to be done, the therapeutic phase follows, in which we strictly follow protein-free and biocompatible trends. All materials are carefully selected and body-friendly. In surgery, we use techniques such as PRF, ozone, and PMP – pulsed magnetic field after procedures. These approaches allow us to avoid the use of antibiotics, significantly reducing complications and pain after procedures. In the field of dentures and bridges, we exclusively practice digital dentistry, which provides excellent precision and comfort. If you experience anxiety, we also offer inhalation sedation, “laughing gas,” to provide relaxation before and during procedures.
Blood Tests to Determine the Impact of the Mouth on the Body
- For those who have already been diagnosed with any condition and wish to understand its causes and eliminate them.
- For individuals who have experienced illness and are in the rehabilitation phase in one way or another.
- For those who perceive symptoms of imbalance but have not yet developed specific disease signs.
- For healthy individuals who want to strengthen their body and mind and maintain their well-being in the long run.